CRISPR/Cas9-Assisted Microrobots for Fast and Ultrasensitive “On-The-Fly” Next-Generation DNA Detection
Fast, sensitive, and selective nucleic acids detection is essential for applications in clinical diagnostics, food safety, and environmental monitoring. Hence, in this study, we introduce a novel motion-assisted CRISPR/Cas9 microrobots-based biosensor, consisting of CRISPR/Cas9 functionalized on gold microrobots (Au–MRs) forming CRISPR/Cas9@Au–MRs, which exhibit self-propulsion leading to rapid and ultrasensitive detection of target DNA. The proposed …
